Nonsense-Mediated mRNA Decay: Splicing, Translation And mRNP Dynamics
β Scribed by Maquat, Lynne E.
- Book ID
- 109958068
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 235 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1471-0072
- DOI
- 10.1038/nrm1310
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π SIMILAR VOLUMES
Nonsense-mediated mRNA decay (NMD) is a process of mRNA surveillance that degrades transcripts harboring a premature termination codon (PTC). Mammalian NMD was mostly studied in cultured cells so far and there was no direct evidence yet that NMD could operate in the brain. We introduced, by homologo
## Abstract Nonsenseβmediated mRNA decay (NMD) is an mRNA surveillance system that eliminates aberrant mRNAs containing premature translation termination codons (PTCs). We evaluated the role of NMD in of Ullrich's disease. The patient has a frameshift mutation with a PTC in the collagen VI Ξ±2 gene
Carpenter syndrome, a rare autosomal recessive disorder characterized by a combination of craniosynostosis, polysyndactyly, obesity, and other congenital malformations, is caused by mutations in __RAB23__, encoding a member of the Rab-family of small GTPases. In 15 out of 16 families previously repo