Mutations in the nonstructural protein 5A gene and virological response to interferon in Turkish patients chronically infected with hepatitis C virus type 1b
β Scribed by H. Akkiz; Salih Colakoglu; Yilmaz Ergun; Macit Sandikci; Mehmet Serin; Murat Oksuz; Fatih Isiksal; Fatim Kacak; B. Abayli
- Book ID
- 119527345
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 134 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0168-8278
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A region associated with sensitivity to interferon (IFN) has been identified previously in the nonstructural protein 5A (NS5A) of hepatitis C virus (HCV) genotype 1b. A study was undertaken to determine whether the presence of mutations in the NS5A 2209-2248 sequence could serve as a predictor of re
## An association has been reported between mutations in the amino acid residues 2209-2248 of the nonstructural protein 5A (NS5A) gene (interferon-sensitivity determining region [ISDR]) and interferon efficacy in hepatitis C virus (HCV)-1b infection. This relationship was analyzed in chronic HCV-2
The response rate to interferon alfa (IFN-alpha) in patients infected with hepatitis C virus (HCV) genotype 1 isolates is poor. A region associated with sensitivity to IFN has been identified in subtype HCV-1b isolates from Japanese patients in the carboxyterminal half of the nonstructural protein N
## Abstract The nonstructural 5B (NS5B) protein of hepatitis C virus possesses RNAβdependent RNA polymerase activity and plays an essential role in viral replication. The mutations in NS5B were determined and the correlation with viral load and response to interferon (IFN) were assessed. The entire