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Mutations in the Chinese hamster ovary cell GART gene of de novo purine synthesis

✍ Scribed by Aaron J. Knox; Christine Graham; John Bleskan; Gary Brodsky; David Patterson


Book ID
116508162
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
499 KB
Volume
429
Category
Article
ISSN
0378-1119

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Chinese hamster ovary (CHO) cells were exposed to 2-acetylaminofluorene (2-AAF) and 2-aminofluorene (2-AF), and several of their N-oxidized metabolites in order to study the mechanisms by which arylamides and arylamines produce mutations in mammalian cells. The number of mutations induced at the hyp