Mutations in NR4A2 associated with familial Parkinson disease
β Scribed by Le, Wei-dong; Xu, Pingyi; Jankovic, Joseph; Jiang, Hong; Appel, Stanley H.; Smith, Roy G.; Vassilatis, Demetrios K.
- Book ID
- 109918165
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 644 KB
- Volume
- 33
- Category
- Article
- ISSN
- 1061-4036
- DOI
- 10.1038/ng1066
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## Abstract Parkinson's disease (PD) is characterized by progressive dopaminergic neuronal loss in the substantia nigra. The recent discovery of __leucineβrichβrepeat kinase 2__ gene (__LRRK2__) mutations in PD is significant because these mutations are the most common cause of autosomal dominant P
FIG. 1. MRI showed symmetric (A) hypointensity signal on T1weighted imaging and (B) hyperintensity signal on T2-weighted imaging in bilateral substantia nigra on admission. A repeated MRI after 3 months showed resolution of the lesions on (C) T2-weighted imaging and (D) T1-weighted imaging.