A striking association has been demonstrated recently between mutations in amino acid residues 2209-2248 of the nonstructural protein 5a (NS5a) region of hepatitis C virus (HCV) and sustained responses to interferon in Japanese patients infected with genotype 1b. Therefore, analysis of this sequence
Mutations in ISDR of NS5A gene influence interferon efficacy in Chinese patients with chronic hepatitis C virus genotype 1b infection
β Scribed by Chuanlai Shen; Ting Hu; Ling Shen; Lei Gao; Wei Xie; Jianqiong Zhang
- Book ID
- 108951042
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 151 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0815-9319
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Patients infected with hepatitis C virus (HCV) genotype 3 have a better response to interferon-β£ (IFN-β£) therapy than those infected with genotype 1. There are extensive sequence differences between genotypes in the 3Π half of the NS5a gene. An association between IFN-β£ response and the interferon s
A region associated with sensitivity to interferon (IFN) has been identified previously in the nonstructural protein 5A (NS5A) of hepatitis C virus (HCV) genotype 1b. A study was undertaken to determine whether the presence of mutations in the NS5A 2209-2248 sequence could serve as a predictor of re