Mutations in breast cancer
β Scribed by Cropp, Craig S.
- Book ID
- 122955165
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 653 KB
- Volume
- 90
- Category
- Article
- ISSN
- 0304-3835
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We analyzed germline mutations of the BRCAl gene in 20 German breast/ovarian-cancer families. BRCA I mutations cosegregating with breast-cancer susceptibility were identified in 3 of these families. All mutations were found to generate a premature stop codon leading to the synthesis of truncated BRC