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Frequent Mutations in Breast Cancer

✍ Scribed by ROBERT CALLAHAN; DANIEL GALLAHAN; GILBERT SMITH; CRAIG CROPP; GIORGIO MERLO; FRANCESCA DIELLA; DANIEL LISCIA; ROSETTE LIDEREAU


Book ID
119868200
Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
548 KB
Volume
698
Category
Article
ISSN
0890-6564

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Prognostic significance of p53 mutation
✍ Pierre O. Chappuis; Anne Estreicher; Barbara Dieterich; HervΓ© Bonnefoi; MichΓ¨le πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 French βš– 123 KB πŸ‘ 1 views

p53 status was tested in 180 patients with primary breast cancer using a yeast functional assay. Mutations were identified in 32% of cases. Only half were point missense mutations; the remainder were nonsense, insertion, deletion and splice site mutations. Twenty-two percent of mutations were locate