MSH6 germline mutations are rare in colo
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Paolo Peterlongo; Khedoudja Nafa; Gabriel S. Lerman; Emily Glogowski; Jinru Shia
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Article
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2003
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John Wiley and Sons
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French
โ 404 KB
๐ 1 views
Germline mutations in MSH6 can cause HNPCC, which is associated with a tumor phenotype featuring MSI. However, tumors arising in persons with disease-causing mutations of MSH6 may or may not exhibit MSI. We used D-HPLC to screen for germline mutations in the promoter region, the coding region and th