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Mutational status of IgVH genes in B-cell chronic lymphocytic leukemia and prognosis: percent mutations or antigen-driven selection?

✍ Scribed by Bomben, R; Dal Bo, M; Zucchetto, A; Zaina, E; Nanni, P; Sonego, P; Del Poeta, G; Degan, M; Gattei, V


Book ID
110056352
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
88 KB
Volume
19
Category
Article
ISSN
0887-6924

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## Abstract ## Background: Expression of T cell specific zeta‐associated protein 70 (ZAP‐70) by B‐cell chronic lymphocytic leukemia (B‐CLL) cells, as investigated by flow cytometry, has both prognostic relevance and predictive power as surrogate for immunoglobulin heavy chain variable region (IgV~