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Are surrogates of IGHV gene mutational status useful in B-cell chronic lymphocytic leukemia? The example of Septin-10

✍ Scribed by Benedetti, D; Bomben, R; Dal-Bo, M; Marconi, D; Zucchetto, A; Degan, M; Forconi, F; Del-Poeta, G; Gaidano, G; Gattei, V


Book ID
110058376
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
101 KB
Volume
22
Category
Article
ISSN
0887-6924

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## Abstract We report high expression of the maternally imprinted gene __PEG10__ in high‐risk B‐CLL defined by high __LPL__ mRNA expression. Differential expression was initially identified by microarray analysis and confirmed by real time PCR in 42 B‐CLL patients. mRNA expression ranged from 0.3‐