✦ LIBER ✦

Mutational spectrum of ICR-191 at the hprt locus in human lymphoblastoid cells

✍ Scribed by Sharon A. Taft; Howard L. Liber; Thomas R. Skopek

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 481 KB
Volume: 23
Category: Article
ISSN: 0893-6692
DOI: 10.1002/em.2850230204

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Splicing mutations at the HPRT locus in

Splicing mutations at the HPRT locus in human T-lymphocytes in vivo

✍ Anne-May Österholm; Sai-Mei Hou 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 183 KB 👁 3 views

We studied 58 splicing mutations originating in observed. The predicted change in three of the base vivo at the hypoxanthine guanine phosphoribosyl-substitutions would be a stop codon. The tandem transferase (HPRT) locus in T-cells of 30 nonsmoking mutation (CC r TT) occurred at position 550-551, ma

Acetaldehyde-induced mutation at the hpr

Acetaldehyde-induced mutation at the hprt Locus in Human Lymphocytes In Vitro

✍ Sai-Mei He; Bo Lambert; J. J. McCormick 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 791 KB

Nitric oxide–induced mutations in the HP

Nitric oxide–induced mutations in the HPRT gene of human lymphoblastoid TK6 cells and in Salmonella typhimurium

✍ John C. Zhuang; Teresa L. Wright; Teresa deRojas-Walker; Steven R. Tannenbaum; G 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 84 KB 👁 1 views

Characterization of mutations induced by NO in different experimental systems will facilitate elucidation of mechanisms underlying its genotoxicity. The mutagenic specificity of NO in human cells is of particular interest in view of its potential role in inflammation-associated carcinogenesis. We co

Structural and functional analysis of mu

Structural and functional analysis of mutations at the human hypoxanthine phosphoribosyl transferase (HPRT1) locus

✍ Jianxin Duan; Lennart Nilsson; Bo Lambert 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 503 KB

## Communicated by Steve S. Sommer Hypoxanthine phosphoribosyl transferase (HPRT, also known as HGPRT) is an often-used genetic marker in eukaryotic cells. The gene is conserved from bacteria to human, with retained catalytic activity, although substrate specificity may have changed, and the enzym

Analysis of mutational changes at the HL

Analysis of mutational changes at the HLA locus in single human sperm

✍ Mei-Mei Huang; Henry A. Erlich; Myron F. Goodman; Norman Arnheim 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 728 KB

Using a simple and efficient single sperm PCR and direct sequencing method, we screened for HLA-DPB1 gene mutations that may give rise to new alleles at this highly polymorphic locus. More than 800 single sperm were studied from a heterozygous individual whose two alleles carried 16 nucleotide seque

Mutational specificity of 2-amino-3-meth

Mutational specificity of 2-amino-3-methylimidazo-[4,5-f]quinoline in the hprt locus of CHO-K1 cells

✍ Huei Lee; Ming-Kuei Shih 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 572 KB

## Abstract 2‐Amino‐3‐methylimidazo[4,5‐__f__]quinoline (IQ), a food carcinogen formed in cooked meats, can induce gene mutation at the __hprt__ locus of CHO‐K1 cells in the presence of hepatic 59 mix. To elucidate the molecular nature of IQ‐induced mutation, we characterized the entire coding regi