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Mutational spectrum of 1,3-butadiene and metabolites 1,2-epoxybutene and 1,2,3,4-diepoxybutane to assess mutagenic mechanisms

โœ Scribed by Leslie Recio; Ann-Marie Steen; Linda J Pluta; Kathy G Meyer; Christopher J Saranko


Book ID
114008768
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
147 KB
Volume
135-136
Category
Article
ISSN
0009-2797

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1,3-Butadiene was incubated in the presence of rat liver microsomes supplemented with an NADPH-generatin, y = s stem. One of the major metabolites of butadiene was found to be 1,2\_epoxybutene-3, which was analysed by electron&pture gas-liquid chromatography after its derivatization with pentafluoro