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Mutational Landscape of the Essential Autophagy Gene BECN1 in Human Cancers

✍ Scribed by Laddha, S. V.; Ganesan, S.; Chan, C. S.; White, E.

Book ID
121814854
Publisher
American Association for Cancer Research
Year
2014
Tongue
English
Weight
387 KB
Volume
12
Category
Article
ISSN
1541-7786

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In primary breast cancer, mutations of the p53 tumor suppressor gene lead to loss of growth-suppressive properties and poor outcome. Recently, a p53-related gene, termed p73, has been cloned and its gene product possesses a function similar to p53. p73 has been mapped at chromosome 1p36.3, a region