## Abstract We sequenced the entire mitochondrial genome in 8 chromophobe renal cell carcinomas (RCCs) and corresponding normal kidneys. Our study disclosed 68 known and 45 new sequence variations occurring 132 and 45 times, respectively. We found 6 somatic nucleotide changes in 5 out of the 8 chro
Mutational landscape of chromophobe renal cell carcinoma
β Scribed by LaFlamme, Brooke
- Book ID
- 127389386
- Publisher
- Nature Publishing Group
- Year
- 2014
- Tongue
- English
- Weight
- 97 KB
- Volume
- 46
- Category
- Article
- ISSN
- 1061-4036
- DOI
- 10.1038/ng.3110
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## Background: Chromophobe renal cell carcinoma (rcc) is a distinctive subtype of rcc with a more favorable prognosis than clear cell rcc. we describe the pathologic features of 23 solitary cases and 2 cases with coexistent papillary rccs, 7 of which developed metastases. ## Methods: Cases were r
Loss of chromosomes 1, 2, 6, 10, 13, 17, and 21 is a characteristic finding in chromophobe renal-cell carcinoma (ChRCC). Previously, cytogenetic and molecular genetic techniques were used in demonstrating the chromosomal monosomies in ChRCCs. We performed interphase fluorescent in situ hybridization