Mutational and expression analysis of the chromosome 12p candidate tumor suppressor genes in pre-B acute lymphoblastic leukemia
β Scribed by Montpetit, A; Larose, J; Boily, G; Langlois, S; Trudel, N; Sinnett, D
- Book ID
- 110055964
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 137 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0887-6924
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## Abstract Deletion of the long arm of chromosome 9, del(9q), is a recurring chromosomal aberration in acute myeloid leukemia (AML) that is frequently associated with t(8;21). The critical gene products affected by del(9q) are unknown but likely cooperate with the __AML1/ETO__ fusion gene created
## Background: The authors have determined the prognostic significance of cytogenetically detectable 12p abnormalities, which are frequent in children with acute lymphoblastic leukemia (all), in a large cohort of patients treated on risk-adjusted protocols of the children's cancer group (ccg). ##