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Mutational analysis of TP53 and p21 in familial and sporadic ovarian cancer in Japan

✍ Scribed by Takayuki Amikura; Masayuki Sekine; Yasuo Hirai; Seiichiro Fujimoto; Masayuki Hatae; Iwao Kobayashi; Tsuneo Fujii; Ichiro Nagata; Kimio Ushijima; Koshiro Obata; Mitsuaki Suzuki; Mitsuhiro Yoshinaga; Naohiko Umesaki; Shinji Satoh; Takayuki Enomoto; Satoru Motoyama; Koji Nishino; Kazufumi Haino; Kenichi Tanaka

Book ID: 113960262
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 220 KB
Volume: 100
Category: Article
ISSN: 0090-8258
DOI: 10.1016/j.ygyno.2005.09.010

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Mutations in the TP53 gene are considered to be among the most common genetic alterations in human cancers. Both somatic and germline mutations have been found. Using polymerase chain reaction (PCR). constant denaturant gel electrophoresis (CDGE), and denaturing gradient gel electrophoresis (DGGE),