Mutational analysis of the PTEN gene in human uterine sarcomas
β Scribed by Johnathan M. Lancaster; John I. Risinger; Michael E. Carney; J.Carl Barrett; Andrew Berchuck
- Book ID
- 114487282
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 185 KB
- Volume
- 184
- Category
- Article
- ISSN
- 1097-6868
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The PTEN gene, recently identified on chromosome 10q23, has been proposed to be a candidate tumor suppressor gene inactivated in multiple cancers including glial tumors. We investigated 47 glioblastomas (GBM), 14 anaplastic astrocytomas (AA), 6 non-pilocytic low-grade astrocytomas (LGA), 21 low-grad
## Loss of heterozygosity (LOH ) at chromosome band 10q23 occurs frequently in a wide variety of human tumors. A recently identified candidate tumor suppressor gene, PTEN located on 10q23, is mutated in multiple advanced cancers. To explore whether PTEN is associated with human squamous cell carci