## Abstract Lung adenocarcinomas often metastasize to the brain, and the prognosis of patients with brain metastases is still very poor. The __epidermal growth factor receptor__ (__EGFR__) gene is mutated in a considerable fraction of primary lung adenocarcinomas, in particular those with drastic r
β¦ LIBER β¦
Mutational analysis of EGFR and K-RAS genes in lung adenocarcinomas
β Scribed by Young Hwa Soung; Jong Woo Lee; Su Young Kim; Si Hyung Seo; Won Sang Park; Suk Woo Nam; Sang Yong Song; Joung Ho Han; Cheol Keun Park; Jung Young Lee; Nam Jin Yoo; Sug Hyung Lee
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 181 KB
- Volume
- 446
- Category
- Article
- ISSN
- 1432-2307
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## Abstract We investigated point mutational activation of the __ras__ genes (Kβ__ras__ codons 12, 13 and 61; Nβ__ras__ codons 12, 13 and 61; Hβ__ras__ codons 12 and 61) in primary, resected lung cancer by dot blotting and oligonucleotide hybridization. Kβ__ras__ mutations were found in 14 (29%) of