Mutation screening of BRCA1 exon 11 in Bulgarian breast cancer families
β Scribed by A. Mitkova; R. Dodova; A. Vlahova; T. Dikov; T. Sedloev; A. Jonkov; I. Kremensky; S. Christova; R. Kaneva
- Book ID
- 119598795
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 85 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1359-6349
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
We analyzed germline mutations of the BRCAl gene in 20 German breast/ovarian-cancer families. BRCA I mutations cosegregating with breast-cancer susceptibility were identified in 3 of these families. All mutations were found to generate a premature stop codon leading to the synthesis of truncated BRC
We have screened index cases from 25 Russian breast/ovarian cancer families for germ-line mutations in all coding exons of the BRCA1 and BRCA2 genes, using multiplex heteroduplex analysis. In addition we tested 22 patients with breast cancer diagnosed before age 40 without family history and 6 patie