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Mutation of Celsr1 Disrupts Planar Polarity of Inner Ear Hair Cells and Causes Severe Neural Tube Defects in the Mouse

โœ Scribed by John A. Curtin; Elizabeth Quint; Vicky Tsipouri; Ruth M. Arkell; Bruce Cattanach; Andrew J. Copp; Deborah J. Henderson; Nigel Spurr; Philip Stanier; Elizabeth M. Fisher; Patrick M. Nolan; Karen P. Steel; Steve D.M. Brown; Ian C. Gray; Jennifer N. Murdoch


Book ID
114319910
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
446 KB
Volume
13
Category
Article
ISSN
0960-9822

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The planar cell polarity (PCP) pathway controls the process of convergent extension (CE) during gastrulation and neural tube closure, and has been implicated in the pathogenesis of neural tube defects (NTDs) in animal models and human cohorts. In this study, we analyzed the role of one core PCP gene