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Mutations in the planar cell polarity genes CELSR1 and SCRIB are associated with the severe neural tube defect craniorachischisis

โœ Scribed by Alexis Robinson; Sarah Escuin; Kit Doudney; Michel Vekemans; Roger E. Stevenson; Nicholas D.E. Greene; Andrew J. Copp; Philip Stanier


Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
412 KB
Volume
33
Category
Article
ISSN
1059-7794

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โœ Ciprian M. Bosoi; Valeria Capra; Redouane Allache; Vincent Quoc-Huy Trinh; Patri ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 227 KB

The planar cell polarity (PCP) pathway controls the process of convergent extension (CE) during gastrulation and neural tube closure, and has been implicated in the pathogenesis of neural tube defects (NTDs) in animal models and human cohorts. In this study, we analyzed the role of one core PCP gene