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Mutation and expression of the p53 gene during chemical hepatocarcinogenesis in F344 rats

✍ Scribed by Yan Fu; Weiguo Deng; Yoshihiko Kawarada; Masami Kawagoe; Ying-Zhe Ma; Xinghua Li; Naxin Guo; Takashi Kameda; Kunihiko Terada; Toshihiro Sugiyama


Book ID
114147761
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
689 KB
Volume
1628
Category
Article
ISSN
0167-4781

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## Abstract Abnormalities of the __p53__ gene are frequently observed in human tumors, including urinary bladder carcinoma, suggesting that __p53__ plays an important role in human carcinogenesis. However, its role in rat bladder carcinogenesis is unclear. We investigated __p53__ gene mutations and

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## Abstract __p53__ genes were analyzed for mutations and expression in a series of 24 tumors or hyperplastic lesions of the urinary bladder induced in F344 rats by carcinogen treatment. Of these, 18 were analyzed as short‐term urothelial cultures. Polymerase chain reaction–single‐strand conformati