Mutational specificity: Mutational spect
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Reginald Davies; Victor I. C. Oreffo; Stuart Bayliss; Phuong-Anh Dinh; Kathryn S
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Article
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1996
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John Wiley and Sons
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English
⚖ 320 KB
👁 2 views
Tamoxifen, an important drug in breast cancer treatment, causes liver cancer in rats. The standard range of in vitro tests have failed to show that it causes DNA damage, but 32P-postlabelling and DNA-binding studies have shown that tamoxifen forms DNA adducts in rat liver. In 1995 a transgenic rat (