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P1B53 - Studies on tamoxifen — induced mutations in the livers and uteri of big blue™ transgenic F344 rats

✍ Scribed by J.A. Styles; R. Davies; S. Fenwick; J. Walker; E. Martin; I.N.H. White; L.L. Smith


Book ID
119539940
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
264 KB
Volume
95
Category
Article
ISSN
0378-4274

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Tamoxifen, an important drug in breast cancer treatment, causes liver cancer in rats. The standard range of in vitro tests have failed to show that it causes DNA damage, but 32P-postlabelling and DNA-binding studies have shown that tamoxifen forms DNA adducts in rat liver. In 1995 a transgenic rat (