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Mutation Analysis of hMSH2 and hMLH1 in Colorectal Cancer Patients in India

✍ Scribed by Rajkumar, Thangarajan; Soumittra, Nagasamy; Pandey, Durgatosh; Nancy, Karunakaran Nirmala; Mahajan, Vikas; Majhi, Urmila

Book ID
121675099
Publisher
Mary Ann Liebert
Year
2004
Tongue
English
Weight
679 KB
Volume
8
Category
Article
ISSN
1090-6576

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We have screened 17 Southern Sweden individuals/families with suspected hereditary non-polyposis colorectal cancer (HNPCC) for mutations in the DNA-mismatch repair genes hMLH1, hMSH2 and hMSH6 using denaturing gradient gel electrophoresis, protein truncation test and direct DNA sequencing. The famil