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Mutants yield a pharmacophore model for the tubulin–paclitaxel binding site

✍ Scribed by Billy W Day


Book ID
117340385
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
103 KB
Volume
21
Category
Article
ISSN
0165-6147

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Epothilone is a recently discovered compound that appears to bind at the same microtubule-binding site as the anticancer agent taxol. A model for the pharmacophore common to these structurally dissimilar compounds is presented.