✦ LIBER ✦

A model for the taxol (paclitaxel)/epothilone pharmacophore

✍ Scribed by Jeffrey D. Winkler; Paul H. Axelsen

Book ID: 104364701
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 222 KB
Volume: 6
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(96)00555-0

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✦ Synopsis

Epothilone is a recently discovered compound that appears to bind at the same microtubule-binding site as the anticancer agent taxol. A model for the pharmacophore common to these structurally dissimilar compounds is presented.

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