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Mutant p53 Alleles Can Be Restored to the Wild-Type Conformation

✍ Scribed by Wurm, Stephen A.; Mühlhäusler, Peter; Tryon, Darrell T.


Book ID
111958292
Publisher
American Association for Cancer Research
Year
2012
Tongue
English
Weight
502 KB
Volume
2
Category
Article
ISSN
2159-8274

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## Abstract The aminothiol WR1065, the active metabolite of the cytoprotector amifostine, exerts its antimutagenic effects through free‐radical scavenging and other unknown mechanisms. In an earlier report, we showed that WR1065 activates wild‐type p53 in MCF‐7 cells, leading to p53‐dependent arres