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Understanding wild-type and mutant p53 activities in human cancer: new landmarks on the way to targeted therapies

โœ Scribed by Goldstein, I; Marcel, V; Olivier, M; Oren, M; Rotter, V; Hainaut, P


Book ID
109842754
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
467 KB
Volume
18
Category
Article
ISSN
0929-1903

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The p53 null HL-60 cell line was transfected with plasmids coding for either the wild-type p53 or mutant p53 gene. The stable expression of wild-type p53 resulted in a significant increase in sensitivity to the topoisomerase II poisons etoposide and doxorubicin, but not to the topoisomerase II inhib