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Mutant IDH1 inhibits PI3K/Akt signaling in human glioma

✍ Scribed by Birner, Peter; Pusch, Stefan; Christov, Christo; Mihaylova, Stiliana; Toumangelova-Uzeir, Kalina; Natchev, Sevdalin; Schoppmann, Sebastian F.; Tchorbanov, Andrey; Streubel, Berthold; Tuettenberg, Jochen; Guentchev, Marin

Book ID
121748742
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
497 KB
Volume
120
Category
Article
ISSN
0008-543X

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✍ Dae-Hee Lee; Miroslaw-Jerzy Szczepanski; Yong J. Lee πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 413 KB

## Abstract We observed that treatment of prostate cancer cells for 24 h with magnolol, a phenolic component extracted from the root and stem bark of the oriental herb __Magnolia officinalis__, induced apoptotic cell death in a dose‐ and time‐dependent manner. A sustained inhibition of the major su