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Mutant Chinese hamster ovary cells with defective methotrexate uptake are distinguishable by reversion analysis

✍ Scribed by T. Michael Underhill; Wayne F. Flintoff

Book ID
112557708
Publisher
Springer
Year
1989
Tongue
English
Weight
696 KB
Volume
15
Category
Article
ISSN
1572-9931

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## Abstract A mutant (A204) of Chinese hamster ovary cells (CHO‐K1), which is deficient in dihydroorotate (DHO) dehydrogenase (E.C. 1.3.3.1) activity, has been isolated by a replica plating procedure. The mutant does not show a requirement for exogenously added pyrimidines. Examination of intact ce