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Mutagenicity studies with 6-mercaptopurine: I. Cytogenetic activity in vivo

โœ Scribed by Henry E. Holden; Verne A. Ray; Margitta G. Wahrenburg; Jane D. Zelenski


Book ID
116036691
Publisher
Elsevier Science
Year
1973
Tongue
English
Weight
453 KB
Volume
20
Category
Article
ISSN
0027-5107

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โœ Frohberg, H. ;Schulze Schencking, M. ๐Ÿ“‚ Article ๐Ÿ“… 1975 ๐Ÿ› Springer-Verlag โš– 794 KB

The chromosome-damaging effect of 6-mercaptopurine (6-MP) was investigated in bone marrow cells of rats, Chinese hamsters, and mice after single intraperitoneal injections of doses from 3.125 to 250 mg/kg, and after multiple applications of 10, 25, 50, and 125 mg/kg. The optimal time of investigatio