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An in vitro and in vivo study on mutagenic activity of fluoranthene: comparison between cytogenetic studies and HPLC analysis

✍ Scribed by F. Palitti; R. Cozzi; M. Fiore; F. Palombo; C. Polcaro; G. Perez; E. Possagno


Book ID
113254864
Publisher
Elsevier Science
Year
1986
Weight
350 KB
Volume
174
Category
Article
ISSN
0165-7992

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Alclofenac (A) and two of its metabolites, dihydroxyalclofenac (DHA) and alclofenac epoxide (AE), were tested for their mutagenic potential. Alclofenac and DHA showed no mutagenic, transforming or clastogenic potential in any in vitro experiment. The addition of a supplementary metabolic activation