Mutagenicity of (R) and (S) styrene 7,8-oxide and the intermediary mercapturic acid metabolites formed from styrene 7,8-oxide
✍ Scribed by Pagano, Dennis A. ;Yagen, Boris ;Hernandez, Oscar ;Bend, John R. ;Zeiger, Errol
- Book ID
- 102836134
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1982
- Weight
- 521 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0192-2521
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## Abstract 7‐(2‐Hydroxy‐1‐phenylethyl)‐ and 7‐(2‐hydroxy‐2‐phenylethyl)guanines are important DNA adducts which can be used as markers of exposure to styrene. Two synthetic routes leading to these compounds are presented using allyl‐protected bromohydrins as synthetic equivalents of styrene oxide
On page 510 of the original article, [1] Scheme 3 has been inadvertently repeated as Scheme 4; the missing correct Scheme 4 is given below. Scheme 4. Preparation of O 6 -arylguanines: (i) K 2 CO 3 and DBU in DMF; 50 °C, 2 d for 22, 65 °C, 3 d for 23-25.
V6rit6(1), Sabine M6nager(l), Christian Car6(2), Dominique Andr6(1 ), Jean d'Angelo\*(2), Gilbert Revial(3), Claude Comber Farnoux(2) and Olivier Lafont\*(1)