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Syntheses of 7-(2-Hydroxy-1-phenylethyl)- and 7-(2-Hydroxy-2-phenylethyl)guanine, DNA Adducts Derived from Styrene 7,8-Oxide

✍ Scribed by Jan Novák; Igor Linhart; Hana Dvorˇáková

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
222 KB
Volume
2004
Category
Article
ISSN
1434-193X

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✦ Synopsis

Abstract

7‐(2‐Hydroxy‐1‐phenylethyl)‐ and 7‐(2‐hydroxy‐2‐phenylethyl)guanines are important DNA adducts which can be used as markers of exposure to styrene. Two synthetic routes leading to these compounds are presented using allyl‐protected bromohydrins as synthetic equivalents of styrene oxide to alkylate 2‐amino‐6‐chloropurine or 7‐methyl‐10‐oxo‐9,10‐dihydropyrimido[1,2‐a]purine as precursors to guanine. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)

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