Nitroguanidine (NG) and its degradation product nitrosoguanidine (NSG) were evaluated for their mutagenic potential by using Drosophila melanogaster sex-linked recessive lethal (SLRL) assay. Following 72 h of feeding exposure, NG and NSG at concentrations of 4-8 pg ml-' and 15-20 mg ml-I, respective
Mutagenicity of Combretum erythrophyllum in sex-linked recessive lethal test in Drosophila
โ Scribed by Youvraj R. Sohni; P. G. Kale
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 41 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0951-418X
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โฆ Synopsis
The roots of the herb Combretum erythrophyllum are prescribed and consumed as a medicine for sexual diseases, as an aphrodisiac, as a purgative and for treating leprosy. This plant is also a source of gums used as food adulterants. In earlier studies, the aqueous extract of this plant induced oxidative and base-pair mutations in Salmonella. We employed the sex-linked recessive lethal test to evaluate its mutagenicity in Drosophila melanogaster. In the current paper we report that the aqueous extract causes mutations in the meiotic stage of Drosophila melanogaster.
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