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Mutagenicity of 3-chlorodibenzofuran and its metabolic activation

✍ Scribed by Michi Matsumoto; Mitsuru Ando; K. E. Mortelmans

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
729 KB
Volume
17
Category
Article
ISSN
0893-6692

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The mutagenicity of tetrachloroethene (tetra) and its S conjugate, S-(1,2,2-trichlorovinyl)glutathione (TCVG) was investigated using a modified Ames preincubation assay. TCVG was a potent mutagen in presence of rat kidney particulate fractions containing high concentrations of y-glutamyl transpeptid