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Mutagenicity and genotoxicity of ethylvinyl ketone in bacterial tests

✍ Scribed by Christoph Deininger; Erwin Eder; Tilmann Neudecker; Christian Hoffman

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 373 KB
Volume: 10
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.2550100305

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✦ Synopsis

The mutagenic and genotoxic effects of ethylvinyl ketone were investigated. This a, P-unsaturated carbonyl compound is widely distributed in the environment, in particular in food. Whereas ethylvinyl ketone shows only weak genotoxicity in the SOS Chromotest with Escherichia coli PQ37, it was distinctly mutagenic per se in the Salmonella preincubation assay with TA100. Using SKF 525 (an inhibitor of microsomal monooxygenase) and trichloropropene oxide (an inhibitor of epoxide hydrolase) we found indication for additional activation via epoxidation by S9 mix. The need for further investigation of the genotoxic, mutagenic and carcinogenic effects of this compound is strongly indicated.

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