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Mutagenic DNA Polymerase in Human Leukemic Cells

✍ Scribed by Clark F. Springgate and Lawrence A. Loeb

Book ID
123651486
Publisher
National Academy of Sciences
Year
1973
Tongue
English
Weight
907 KB
Volume
70
Category
Article
ISSN
0027-8424

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The Long PCR followed by the RFLP technique has been used to search for abnormally structured mitochondrial DNA (mtDNA) and specific sequence differences implicated in the pathogenesis of acute lymphoblastic leukaemia (ALL). We have studied 54 specific sites whose combinations define groups of mtDNA