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Mutagenesis Studies Investigating Slow Inactivation of Sodium Channel Nav1.6

✍ Scribed by Lampert, Angelika; O'Reilly, Andrias; Eberhardt, Esther


Book ID
122183552
Publisher
Biophysical Society
Year
2013
Tongue
English
Weight
53 KB
Volume
104
Category
Article
ISSN
0006-3495

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## Abstract The sodium channel gene __Scn8a__ encodes the channel Na~V~1.6, which is widely distributed in the central and peripheral nervous system. Na~V~1.6 is the major channel at the nodes of Ranvier in myelinated axons. Mutant alleles of mouse __Scn8a__ result in neurological disorders includi