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Mutagenesis of the Nuclear Localization Sequence in FGF-1 Alters Protein Stability but Not Mitogenic Activity

✍ Scribed by S. Friedman; X. Zhan; T. Maciag


Book ID
115574205
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
288 KB
Volume
198
Category
Article
ISSN
0006-291X

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## Abstract The roles of the mitogen‐activated kinase protein (MAPK) pathway, nuclear factor‐kappa B (NF‐κB), and activator protein‐1 (AP‐1) in cellular responses to growth factors and mitogen are well established. However, the manner by which these proliferative pathways are affected by the tumor