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High cholesterol diet down regulates the activity of activator protein-1 but not nuclear factor-kappa B in rabbit brain

✍ Scribed by János Kálmán; Bhalchandra J. Kudchodkar; Raghu Krishnamoorthy; Ladislav Dory; Andras G. Lacko; Neeraj Agarwal

Book ID
117172822
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
124 KB
Volume
68
Category
Article
ISSN
0024-3205

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Gpbar1 (TGR5), a membrane-bound bile acid receptor, is well known for its roles in regulation of energy homeostasis and glucose metabolism. TGR5 also displays strong attenuation of macrophage reactivity in vitro, but the physiological roles of TGR5 in inflammatory response, and its mechanism, is unk