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Mutagen-induced chromosome fragility within peripheral blood lymphocytes of head and neck cancer patients

✍ Scribed by Dr. Stimson P. Schantz; T. C. Hsu

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 615 KB
Volume: 11
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.2880110409

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✦ Synopsis

The expression of chromosome breakage as a response to mutagen exposure may contribute to the development of head and neck cancer. Lymphocytes from 46 previously untreated head and neck cancer patients were cultured in vitro and exposed to the radiomimetic clastogen, bleomycin. The lymphocytes were then arrested in metaphase and analyzed for bleomycin-induced chromosome breaks. Mean bleomycin-induced chromosome breaks per cell (b/c) in head and neck cancer patients (0.94 2 0.3 b/c) were significantly higher than in either controls (0.70 * 0.3 b/c; p < 0.001) or a concurrently examined patient population with central nervous system tumors (0.55 -t 0.3 b/c; p < 0.001). The expression of mutagen-induced chromosome fragility in the head and neck cancer population was site-specific, being most evident in patients with laryngeal or pharyngeal cancer but not oral cavity disease. The differential responses to mutagen effects may be a reflection of DNA repair deficiency. Head and neck cancer patients express a higher degree of chromosomal mutagen sensitivity, which may contribute to neoplastic development. HEAD & NECK 11:337-342, 1989 Studies on chromosome instability in some individuals suggest that such a phenotype may have

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