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Mutability of bacteriophage M13 by ultraviolet light: Role of pyrimidine dimers

✍ Scribed by Schaaper, Roeland M. ;Glickman, Barry W.


Publisher
Springer
Year
1982
Tongue
English
Weight
419 KB
Volume
185
Category
Article
ISSN
0026-8925

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The p53 tumor-suppressor gene has been implicated in the inducible activation of excision repair of ultraviolet (UV)-induced cyclobutane pyrimidine dimers (CPDs) in human cells. Because the large T antigen (LTAg) of the simian virus 40 (SV40) binds p53 protein and can interfere with its function, it