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Isolation of ultraviolet light induced pyrimidine dimers from enzymic hydrolyzates of DNA

✍ Scribed by Gary D. Small; Robert B. Sparks


Publisher
Elsevier Science
Year
1971
Tongue
English
Weight
522 KB
Volume
41
Category
Article
ISSN
0003-2697

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The p53 tumor-suppressor gene has been implicated in the inducible activation of excision repair of ultraviolet (UV)-induced cyclobutane pyrimidine dimers (CPDs) in human cells. Because the large T antigen (LTAg) of the simian virus 40 (SV40) binds p53 protein and can interfere with its function, it