Musk xylene is a novel specific inducer of cytochrome P-450IA2
โ Scribed by Nobuhisa Iwata; Ken-ichiro Minegishi; Kazuhiro Suzuki; Yasuo Ohno; Toru Kawanishi; Atsushi Takahashi
- Book ID
- 115765194
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 315 KB
- Volume
- 184
- Category
- Article
- ISSN
- 0006-291X
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The oxidation of uroporphyrinogen, an intermediate of the heme biosynthetic pathway, by methylcholanthrene-inducible isozyme(s) of cytochrome P-450 has been proposed to play a role in the development of chemically induced uroporphyria. Prior work from this laboratory [lo] indicated that although add
Musk xylene (MX) is a synthetic nitromusk perfume ingredient that, although uniformly negative in genotoxicity testing, causes liver tumors in B6C3F1 mice. MX is also capable of inducing cytochrome P450 enzymes in a manner similar to that of phenobarbital (PB), which suggests that epigenetic mechani