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Induction and Inhibition of Mouse Cytochrome P-450 2B Enzymes by Musk Xylene

✍ Scribed by Lois D. Lehman-McKeeman; David R. Johnson; Douglas Caudill

Book ID
112266299
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
203 KB
Volume
142
Category
Article
ISSN
0041-008X

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Induction of mouse cytochrome P450 2B en
Induction of mouse cytochrome P450 2B enzymes by amine metabolites of musk xylene: Contribution of microsomal enzyme induction to the hepatocarcinogenicity of musk xylene
✍ Lois D. Lehman-McKeeman; Sharon B. Stuard; Douglas Caudill; David R. Johnson πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 160 KB πŸ‘ 1 views

Musk xylene (MX) is a synthetic nitromusk perfume ingredient that, although uniformly negative in genotoxicity testing, causes liver tumors in B6C3F1 mice. MX is also capable of inducing cytochrome P450 enzymes in a manner similar to that of phenobarbital (PB), which suggests that epigenetic mechani