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Muscle-specific Pparg deletion causes insulin resistance

✍ Scribed by Hevener, Andrea L; He, Weimin; Barak, Yaacov; Le, Jamie; Bandyopadhyay, Gautam; Olson, Peter; Wilkes, Jason; Evans, Ronald M; Olefsky, Jerrold


Book ID
109933311
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
366 KB
Volume
9
Category
Article
ISSN
1078-8956

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Insulin resistance of skeletal muscle, liver and fat combined with an abnormality of insulin secretion characterizes Type 2 (non-insulin-dependent) diabetes mellitus. There is increasing evidence that the insulin resistance of the skeletal muscle plays a key role early in the development of Type 2 d