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Muscle fiber type-specific myofibrillar Ca2+ ATPase activity after spinal cord injury

✍ Scribed by Michael J. Castro; David F. Apple Jr.; Sandee Melton-Rogers; Gary A. Dudley

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
172 KB
Volume
23
Category
Article
ISSN
0148-639X

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✦ Synopsis

Biopsies of the vastus lateralis muscle were analyzed to determine if increased energy demand of contraction, as indirectly reflected by myofibrillar Ca 2+ adenosine triphosphate activity (qATPase), contributes to greater fatigue in affected muscle of spinal cord injured (SCI) patients. The qATPase activity showed a fiber-type effect, IIax + IIx > IIa > I. Average fiber qATPase and fiber specific qATPase activities were not different between SCI and able-bodied controls, nor did they change over time. We suggest greater fatigue in SCI subjects early after injury does not reflect increased energy demand of contraction.

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