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Muscle fiber type-specific myofibrillar actomyosin Ca2+ ATPase activity in multiple sclerosis

✍ Scribed by Michael J. Castro; Jane A. Kent-Braun; A.V. Ng; Robert G. Miller; Gary A. Dudley

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 34 KB
Volume: 21
Category: Article
ISSN: 0148-639X
DOI: 10.1002/(sici)1097-4598(199804)21:4<547::aid-mus18>3.0.co;2-u

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✦ Synopsis

Biopsies of tibialis anterior muscle were analyzed to determine if increased energy demand of contraction, as indirectly reflected by myofibrillar actomyosin Ca 2+ ATPase (qATPase) activity, contributes to symptomatic fatigue in multiple sclerosis (MS). qATPase activity showed a fiber-type effect, IIax > IIa > I. Fiber-type qATPase activity, however, was not different between MS patients and healthy controls. We suggest that fatigue in MS does not reflect increased energy demand of contraction.

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