The integrity of GABA-A receptors and of central benzodiazepine receptors was evaluated in membrane preparations from prefrontal cortex and caudate nuclei obtained at autopsy from nine cirrhotic patients who died in hepatic coma and an equal number of agematched control subjects. Histopathological s
Muscimol binding and GABA receptors
โ Scribed by Dr. Francis V. DeFeudis
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- English
- Weight
- 887 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0272-4391
No coin nor oath required. For personal study only.
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Autoradiographic studies were conducted on the binding of 3H-GABA and 3H-muscimol in cultures of rat cerebellum. Binding sites for both substances were observed on many cerebellar neurones, such as Purkinje cells and interneurones, but not on glial cells. Binding of 3H-GABA and 3H-muscimol was inhib
## Abstract Muscimol, a GABA agonist, enhanced pentobarbital sleeping time in a doseโdependent manner. The GABA antagonists such as bicuculline and picrotoxin, and the CNS stimulant such as pentylenetetrazol, inhibited pentobarbital sleeping time; however, all except picrotoxin produced less than 3